Science sub qhov teeb meem: Cov roj txheem inert muaj peev xwm txhim kho cov tsos mob ntawm Alzheimer tus kab mob

Alzheimer tus kab mob (Ad) yog ib qho ntawm feem ntau cuam tshuam rau neurological kev kwv yees tau ntau dua 55 lab, nrog ad yog hom feem ntau. Cov kev tshawb fawb uas twb muaj lawm paub tias Beta Amyloid (ib qho) plaques thiab neurofibrillary tangles yog cov kev tshawb fawb tseem ceeb tau ua tiav cov txiaj ntsig no.

Tsis ntev los no, kev sib koom tes ntawm Massachusetts dav dav tsev kho vaj tsev kho mob thiab tau coj los txog qhov tshiab kev kho mob tshiab: Xenon kev kho mob. Cov kws tshawb nrhiav pom tias tom qab nqus tau xenon roj, theem ntawm neuroinelfammelation txo qis, thaum kev pheej hmoo ntawm kev puas tsuaj neuronal kev puas tsuaj. Txawm hais tias nas muaj ib los yog tau protein tangles, Xenon tuaj yeem txo cov txiaj ntsig ntawm kev tshaj tawm thiab txhim kho cov tsos mob. Qhov no yuav nqa cov tswv yim tshiab thiab cov lus qhia rau kev tshawb fawb ad kho.

Hauv kev sim, cov kws tshawb nrhiav ua ntej txhaj apoptotic neurons rau hauv cortex thiab hippocampus ntawm nas Lawv pom tias lub microglia maj mam hloov pauv lawv morphology thiab cov yam ntxwv rau cov phenotype ntawm neurodegenerative micoglia (mgnd). Mgnd yuav plam nws thawj "Tus Tsim Nyog" yog leejtwg, thiab nws cov cim tsis huv feem ntau txhawb nqa mob hauv lub zos thiab ua kom puas tsuaj rau neurons.

Tab sis kev sib ntxiv ntawm xenon roj hloov cov xwm txheej no. Tus kws sau ntawv tau sim kom muaj cov neeg sim ua kom muaj qee qhov kev xav ntawm cov micrortration, thiab cov txiaj ntsig tau pom tias cov kab mob microcytic, thiab txo cov pro-inflamptatore phalotype. The author believes that xenon gas entering the brain reverses the inflammatory phenotype of microglia, causing them to revert back to the pre neurodegenerative state of microglia (pre MGnD).

Ntxiv mus, xenon roj tsis tsuas yog pab micoglia mus rau "hloov pauv", tab sis kuj tseem tseem yuav tau txais kev daws teeb meem thiab kev txhim kho ntawm kev txhim kho. Tus kws sau ntawv xaiv ob hom ad qauv mice, ib qho nrog kev sib hloov hauv amyloid precursor protein protein protein uas ua rau kev tsub zuj zuj (app / ps1 mice); Lwm hom nrog Apoe4 kev sib hloov yog nquag los tsim cov protein tangles (p301s nas).

Ntawm chav kawm, xenon roj yuav tsum tswj hwm tib neeg, thiab seb Xenon roj kuj tseem xav tau kev tshawb fawb ntau dua los tshawb nrhiav. Cov pab pawg tshawb fawb tam sim no tab tom ua lub chaw kuaj mob thaum ntxov los tshawb txog kev nyab xeeb thiab noj tshuaj xenon. Yog tias muaj pov thawj ua tau, rau cov neeg mob yuav tsum tau txais kev kho mob tshiab thiab tshwj xeeb.