Lub ntiaj teb tam sim no tab tom ntsib qhov kev sib tw hnyav ntawm cov neeg laus cov qauv. Nrog rau kev siv zog ntawm kev laus, cov kab mob ntsig txog kev laus ntawm cov cellular xws li daim siab fibrosis, pulmonary fibrosis, mob qog noj ntshav, osteoarthritis, thiab cov kab mob neurodegenerative tau dhau los ua teeb meem kev noj qab haus huv tseem ceeb uas tsis tuaj yeem tsis quav ntsej. Kev pom tias tshem tawm cov hlwb laus muaj peev xwm txo qis lossis txawm tias kho cov kab mob muaj hnub nyoog no tau tsim kev pom zoo hauv thaj chaw. Txawm li cas los xij, yuav ua li cas kom nyab xeeb, ua tau zoo, thiab raug tshem tawm cov hlwb laus tseem yog qhov nyuaj uas yuav tsum tau kov yeej.
Tsis ntev los no, xibfwb Wang Ben pab neeg los ntawm Lub Tsev Kho Mob Thib Ob ntawm Zhejiang University Lub Tsev Kawm Ntawv ntawm Tshuaj / Txhais Tshuaj Tshawb Fawb tau luam tawm ib daim ntawv hauv online hauv phau ntawv journal Nature Aging, thov ib txoj hauv kev tshiab, nyab xeeb, thiab ruaj khov rau tshem tawm cov laus. Txoj kev no tsim cov tshuaj chimeric peptide molecular cov tshuaj uas tshwj xeeb tsom rau cov hlwb laus thiab ua kom lub cev tiv thaiv kab mob, txhawb kev tiv thaiv kab mob hauv lub cev thiab tua cov laus hlwb, yog li txo cov hnub nyoog ntsig txog kab mob. Cov kev sim nas tau pom tias cov tshuaj chimeric peptide molecule tsim los ntawm pab pawg tshawb fawb tuaj yeem tiv thaiv kev laus.
Lub tswv yim ntawm txoj kev tshawb no yog siv chimeric peptide molecules rau "choj" lub cev tiv thaiv kab mob thiab senescent hlwb. Cov kev tshawb fawb yav dhau los tau pom tias glutamate muaj feem cuam tshuam nrog kev so thiab ua kom lub cev tiv thaiv kab mob, thiab tuaj yeem ua tus tswj hwm los pib cov tshuaj tiv thaiv kab mob endogenous; Urokinase hom plasminogen activator receptor (uPAR) yog ib qho ntawm cov protein ntau ntawm tes thiab qhia tshwj xeeb hauv cov hlwb. Yog li, cov kws tshawb fawb tau tsim thiab tsim cov phiaj xwm peptide uPA24 nrog qhov ntev ntawm kwv yees li 24 amino acids raws li qhov sib lawv liag ntawm uPAR tshwj xeeb ligand urokinase hom plasminogen activator (uPA) lub hom phiaj khi thaj tsam. Nws tau ntim nrog 16 qhov rov ua dua ntawm glutamic acid (16E) los tsim lub chimeric peptide E16-uPA24, uas tuaj yeem sau cov hlwb senescent zoo, paub txog lub cev tiv thaiv kab mob los ntawm glutamic acid, thiab txhawb lawv lub cev tiv thaiv kab mob.
Txhawm rau nthuav tawm cov txiaj ntsig ntawm E16-uPA24 ntawm kev tiv thaiv kab mob microenvironment ntawm fibrotic aging, cov kws tshawb fawb tau sau cov ntaub so ntswg ntawm lub siab, cov ntaub so ntswg fibrotic, thiab cov ntaub so ntswg fibrotic kho nrog peptides los ntawm cov nas, thiab siv cov spectrometry flow cytometry rau pawg thiab tshuaj xyuas. lub cev tiv thaiv kab mob. Cov txiaj ntsig tau pom tias piv nrog cov pab pawg siab fibrosis, qhov kev faib ua feem ntawm cov hlwb pro-inflammatory (neutrophils, eosinophils) nyob rau hauv pab pawg kho mob pom tau tias muaj kev poob qis; Qhov feem pua ntawm cov lymphocytes, tshwj xeeb tshaj yog cov neeg tua neeg ntuj (NK) hlwb, nce ntau. Qhov no qhia tau hais tias E16-uPA24 tuaj yeem tswj hwm microenvironment ntawm lub cev laus los ntawm kev txhim kho cytotoxic tua nyhuv ntawm lymphocytes, uas NK hlwb tuaj yeem ua lub luag haujlwm tseem ceeb.
Ntxiv rau hauv vitro thiab hauv vivo kev sim tau pom tias chimeric peptide tuaj yeem tsom uPAR khi rau senescent cell membranes thiab ua rau glutamate receptor 5 (mGluR5) ntawm NK cell membranes, yog li txhim kho NK cell paub thiab tshem tawm ntawm cov hlwb senescent, txhim kho hnub nyoog ntsig txog. cov kab mob xws li mob siab fibrosis thiab mob pulmonary fibrosis, thiab zoo tiv thaiv ntuj kev laus.
Nature Aging tau luam tawm cov kev tshawb fawb luv luv hu ua "Restoring aging related tissue homeostasis via reactive inner immune therapy" tib lub sij hawm, qhia cov kev tshawb fawb tshawb pom thiab tau txais cov lus pom zoo los ntawm xibfwb Juan Carlos Acosta Cobacho thiab Nature Aging editorial team ntawm Cantabria Institute of Biomedical. thiab Biotechnology hauv Spain.
