Nerandomilast yog qhov ncauj me me molecuent uas yog qhov ua rau tsis pub muaj phosphodiesase 4b (PDE4b) thiab muaj ob lub zog tawm thiab anti fibrotic teebmeem. Cov kev txhim kho kev kho mob rau cov tshuaj no suav nrog ob qho kev tshawb fawb rau cov neeg mob fibronary fibronary fibronary pulmonary carmonary fibrosary. Hauv 2022, nws tau txais kev pov thawj kho kev kho mob los ntawm Asmeskas FDA rau kev kho mob ntawm IPF.
PDE4 yog ib tug tswv cuab ntawm phosphodiesterase (PDE4A-PDE4A-PDE4D), uas tuaj yeem tswj hwm cov cytokines tshwj xeeb los ntawm cov chaw pw hydrolying hydrolying hydrolyzing hydrolyzing bet. Kev tshawb fawb tau pom tias muaj kev cuam tshuam PDE4 tuaj yeem nce cov phiaj xwm kev pw hav zoov xws li NF κ B thiab NFAT thiab txo cov kev tso tawm ntawm cov cytopsigne cytokines thiab chemokines. Yog li ntawd, kho cov hom phiaj PDE4 yuav tsum tau ua ntau yam mob cuam tshuam rau cov kab mob muaj feem xyuam.
Ntawm lawv, PDE4B plays lub luag haujlwm hauv kev tswj hwm cov calcium uas muaj cov txiaj ntsig los ntawm kev kho mob pulmonary thaum tsis txhob muaj cov xwm txheej tsis zoo. Txawm li cas los xij, cov chaw nquag ntawm plaub subtypes ntawm PDE4 yog zoo sib xws, thiab feem ntau PDE4 inibitors tsis tuaj yeem paub qhov txawv ntawm kev sib txawv. Qhov no inhibitor los ntawm Boehringerer Ingelheim muaj qhov zoo tshaj plaws hauv kev xaiv - nws muaj cov neeg nyiam nyiam Inhibitia cov nyhuv ntawm PDE4B. Cov ntaub ntawv ua ntej qhia tau tias kev sim ua ke yog feem ntau ua raws li theem 2 Idiopathic kev nyab xeeb ntawm kev nyab xeeb thiab thev taus cov xwm txheej zoo sib piv tau sib piv rau cov pab pawg ntawm thaj chaw.
Lub Cuaj Hli Ntuj kawg, Boothringer Ingelheim tshaj tawm tias Nerandomilast tau ua tiav tus thawj qhov kev kho mob ntawm IPF, tsis muaj kev ua haujlwm ntawm IPF, kho mob ntsws hauv ipf. Cov ntawv tshaj tawm hais tias qhov no yog thawj theem 3 kuaj mob sim hauv IPF teb kom ncav cuag lub Koom Haum Me Nyuam Yaus hauv kaum xyoo. Cov ncauj lus kom ntxaws ntawm fibroneer-ipf thiab fibroneer-ilil yuav tso tawm tom qab xyoo no.
