CAS Nr .: 42464-96-0|5-Amino-1-methylquinolin-1-ium Iodide

Specification:

Qhov tshwm sim	Xim av rau reddish xim av hmoov
Purity (HPLC)	NLT 99%

 

Daim ntawv thov:

5-Amino-1-methylquinolin-1-ium iodide yog ib qho kev xaiv, substrate-competitive inhibitor ntawm nicotinamide N-methyltransferase (NNMT) (IC₅₀=1.2 μM), nrog rau cov kev siv tseem ceeb hauv kev tshawb fawb biomedical, kev tshawb fawb txog kab mob metabolic.

1 Kev Tshawb Fawb Txog Metabolic Disorder

Obesity & Adipogenesis: Inhibits 3T3-L1 adipocyte txawv thiab txo lipogenesis; txo qis 1-methylnicotinamide (1-MNA) qib hauv cov rog rog (EC₅₀=2.3 μM).

Insulin Resistance & Diabetes: Txhim kho insulin rhiab heev thiab qabzib homeostasis los ntawm kev txhim kho NAD⁺ khaws cia thiab mitochondrial muaj nuj nqi.

Hepatic Steatosis: Txo cov rog hauv siab thiab cov nqaij adipose dawb hauv cov qauv ua ntej.

2 Muscle & Aging Biology

Kev kho Sarcopenia: Ua kom cov leeg nqaij leeg (musCs), boosts proliferation / fusion, thiab txhim kho lub peev xwm rov tsim dua tshiab hauv cov nas hnub nyoog.

Kev Kho Cov leeg nqaij: Ua kom rov qab zoo dua tom qab- raug mob uas tsis muaj kab mob toxicity.

Lean Mass Preservation: Ua kom lub cev hnyav ntxiv - rau - qhov hnyav piv hauv cov qauv kab mob metabolic.

3 Cellular & Epigenetic Research

NAD⁺ Metabolism: Hloov cellular "methyl kev lag luam," nce NAD⁺ thiab SAM (S-adenosylmethionine) pas dej.

Epigenetics: Modulates DNA / histone methylation ntawm SAM muaj.

Mitochondrial Function: Txhim kho lub zog tsim thiab oxidative metabolism.

2.4 Kev Tshawb Fawb Txog Oncology

Cancer Metastasis: Txhawb nqa kev mob qog noj ntshav ntawm zes qe menyuam hauv plab hauv cov qauv murine.

Tumor Metabolism: Lub Hom Phiaj NNMT- nthuav tawm cov qog nqaij hlav cancer ntau dhau (piv txwv li, daim siab, hnyuv, zes qe menyuam).

 

 

Synonyms:

NNMTi
5-amino-1MQ
5-Amino-1-methylquinolinium
5-Amino-1methylquinolinium iodide
5-Amino-1-methylquinolin-1-ium iodide
 

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