CAS Nr .: 872511-34-7|Infigratinib
Lub npe: Infigratinib
CAS Nr .: 872511-34-7
Cov mis mos molecular: C26H31Cl2N7O3
Molecular Luj: 560.48
EINECS tus lej:
MDL No.: 22123241
Khoom taw qhia:
Infiglatinib yog ib qho zoo thiab xaiv FGFR inhibitor uas ua rau FGFR1/2/3, nrog IC50 ntawm 0.9 nM / 1.4 nM / 1 nM. Nws qhov kev xaiv ntawm FGFR yog ntau dua 40 npaug ntau dua li ntawm FGFR4 thiab VEGFR2, thiab nws yuav luag tsis muaj kev cuam tshuam rau Abl, Fyn, Kit, Lck, Lyn, thiab Yog. Nws xaiv khi thiab inhibits FGFR kev ua ub no los thaiv cov kev taw qhia qis qis, ua rau cov qog nqaij hlav ntawm tes tuag los ntawm kev txo qis kev mob qog noj ntshav. Haum rau kev kho mob yav dhau los, tsis tuaj yeem kho hauv zos qib siab lossis metastatic cholangiocarcinoma hauv cov neeg laus nrog fibroblast kev loj hlob zoo receptor 2 (FGFR2) fusion lossis lwm yam FDA pom zoo rov kho dua.
Daim ntawv thov:
| Mechanism ntawm Action | Selectively inhibits ATP-binding hnab tshos ntawm FGFR2 fusion proteins, thaiv qhov tsis zoo ntawm cov teeb liab hloov mus rau inhibit qog cell proliferation thiab angiogenesis. |
| Cov lus qhia | Thawj zaug: Kev kho mob yav dhau los, tsis tuaj yeem kho hauv zos siab heev lossis metastatic cholangiocarcinoma (mob qog noj ntshav hauv plab) nrog FGFR2 fusion lossis rov kho dua.Kev tshawb xyuas: mob plab, mob qog noj ntshav, thiab lwm yam qog nqaij hlav nrog FGFR aberrations. |
| Target Patient Population | Cov neeg laus uas tau txais kev kho mob yav dhau los, cholangiocarcinoma siab heev harboring FGFR2 fusions/rearrangements.Feem ntau: FGFR2 aberrations tshwm sim hauv 10-15% ntawm cov mob cholangiocarcinoma. |
| Lwm yam khoom muaj feem xyuam | Pemigatinib (Pemazyre), Futibatinib (Lytgobi), thiab Erdafitinib (Balversa). |
Synonyms:
SIB 398
NVP-BGJ398
872511-34-7
Truseltiq
C26H31Cl2N7O3
Infigratinib
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea
Cim npe nrov: cas 872511-34-7|infigratinib, Suav teb cas 872511-34-7|infigratinib manufacturers, lwm tus neeg
