CAS 16676-29-2|Naltrexone Hydrochloride
Lub npe: Naltrexone hydrochloride
CAS Nr .: 16676-29-2
Cov mis mos molecular: C20H24ClNO4
Molecular Luj: 377.87
EINECS tus lej: 240-723-0
MDL No.: MFCD00069324
Product Overview
Naltrexone hydrochloride (CAS 16676-29-2) yog lub zog, kev sib tw opioid receptor antagonist nrog siab affinity rau mu-opioid (μ-} opioid) receptors thiab ntxiv kev ua ub no ntawm kappa- (κ) thiab delta-(δ.) opioid site. Raws li morphinan derivative, nws thaiv cov endogenous thiab exogenous opioids yam tsis muaj kev ua haujlwm agonist, ua tus qauv siv tshuaj rau kev quav tshuaj neuroscience, kev tshawb fawb neuroinflammation, thiab receptor pharmacology.
Kev Txhaum Neuroscience & Tshuaj Siv Cov Qauv
- Blocks euphoria thiab lub cev dependence uas tau tsav los ntawm exogenous opioid receptor activation nyob rau hauv preclinical qauv.
- Modulates mesolimbic dopamine txoj hauv kev los txo qis kev ntshaw thiab cawv rau tus kheej - kev coj cwj pwm.
- Ua raws li tus neeg saib xyuas kev kho mob rau kev ntsuas kev rov qab los tshiab tshiab -cov qauv kev tiv thaiv thiab kev txhawb nqa - tso tawm cov tshuab xa tawm.
Tsawg-Kuaj Naltrexone (LDN) & Neuroinflammation
- Inhibits Tus Xov Tooj -zoo li receptor 4 (TLR4) taw qhia ntawm cov hlwb microglial txhawm rau txhawm rau pro- inflammatory cytokine tso tawm.
- Txheeb xyuas qhov kev cuam tshuam ntawm opioid receptor blockade los ua kom cov nyiaj them rov qab nce ntxiv hauv kev tsim cov tshuaj endorphin.
- Ua haujlwm raws li cov cuab yeej tshawb fawb hauv qhov mob ntev, fibromyalgia, autoimmune qauv, thiab central sensitization syndromes.
Receptor Pharmacology & CNS Assay
- Siv nyob rau hauv kev sib tw binding thiab radioligand tshem tawm kev soj ntsuam los ua tus yam ntxwv ntawm opioid receptor subtypes.
- Tshawb xyuas hypothalamic{0}}pituitary-adrenal (HPA) axis teb thiab neuroendocrine tswv yim mechanisms.
- Kev ua haujlwm raws li kev siv cov tshuaj tiv thaiv nyob rau hauv siab - dhau los ntawm kev tshuaj ntsuam xyuas rau kev xaiv tshuaj tua kab mob thiab neuropsychiatric leads.
Kev Siv & Kev Siv Chav Ua Haujlwm
Npaj rau kev tshawb fawb soj ntsuam, kuaj biochemical, thiab tshuaj CRO tshuaj tshawb pom ua haujlwm. Khaws ua khoom ntawm 2-8℃lossis chav tsev kub hauv qhov chaw qhuav thiab tsaus, tiv thaiv lub teeb thiab noo noo. Yooj yim soluble hauv aqueous buffers thiab cawv.
Synonyms
Naltrexone HCl; | N-Cyclopropylmethyl-14-hydroxynordihydromorphinone hydrochloride; | (5,17)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxMorphinan-6-ib hydrochloride; | 17-(Cyclopropylmethyl)-4,5 -epoxy-3,14-dihydroxymorphinan-6-ib hydrochloride
Cim npe nrov: cas 16676-29-2|naltrexone hydrochloride, Tuam Tshoj cas 16676-29-2|naltrexone hydrochloride manufacturers, lwm tus neeg
