CAS Nr .: 1225208-94-5|Cefiderocol

Khoom taw qhia:

Cefopidil yog ib yam tshiab ntawm cov tshuaj tua kab mob hlau cephalosporin uas tawg los ntawm cov kab mob tiv thaiv kab mob los ntawm "Trojan nees" mechanism. Nws yog ib qho tshuaj siv los kho cov kab mob loj heev los ntawm carbapenem resistant gram-cov kab mob tsis zoo.

Cov tsos mob: Dawb mus rau cov khoom dawb

Purity: 95% +

 

 

Daim ntawv thov:

Pom zoo indications (FDA / EU / Nyiv):
Cov kab mob urinary complex (cUTI) (xws li pyelonephritis): Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Enterobacter cloacae.
Tsev kho mob tau txais kev mob ntsws / lub tshuab ua pa- mob ntsws associated pneumonia (HAP/VAP): Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacteriaceae.

 

 

Cefiderocol Intermediates:

7-Aminocephalosporanic acid (7-ACA, CAS 957-68-6)
(Z) 2- (2-aminothiazol-4-yl) -2- [(2-carboxyisopropoxy) imino] acetic acid
2-Aminothiazole-4-carboxylic acid, Tevaleric acid, hydroxylamine derivatives
2-Chloro-3,4-dihydroxybenzoic acid (catechol nplhaib)
1- (2-aminoethyl) pyrrolidine (pyrrolidinethylamine)
Methoxybenzyl chloride (PMB Cl, hydroxyl tiv thaiv)
2-Chloro-3,4-dimethoxybenzaldehyde (pib khoom)

 

 

Synonyms:

Fostemsavir

S-649266

1225208-94-5

(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((1-(2-(2-chloro-3,4-) dihydroxybenzamido)ethyl)pyrrolidin-1-ium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2H8] -Cefiderocol

(6R, 7R) -7- [(2Z) -2- (2-amino-1,3-thiazol-4-yl) -2- {[(2-carboxypropan-2-yl) oxy] imino} acetamido] -3- ({1- [2- (2-chloro-3,4-dihydroxybenzamide)-1-methyl-dihydroxybenzamide) -8-oxo-5-thio-1-azabicyclo [4.2.0] oct-2-en-2-carboxylate

2H6] -Cefiderocol

C30H34ClN7O10S2

 

 

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