1257044-40-8 venetoclax

Cov Khoom Siv

Pom lub teeb daj rau cov khoom daj
Melting point:>150 Qib (Dec.)
Ntawj 1.34 {0} ± 0.06 g / cm3
Cia temp. -20} degree lub freezer
Solubility DMSO (me ntsis)
PKA4. {0} 9 ± 0.10
 

Daim Ntawv Thov:

Venetoclax, pom zoo los ntawm FDA rau Tim 11, 2016, yog lub ntiaj teb thawj BCL -2 inhibitor. Cov tshuaj no tsis yog tsuas yog thawj ntawm nws hom ntawm BCL {}} protein inhibuor, tab sis kuj muaj kev sib cuam tshuam cov protein ntau, kos cim rau kev sib txuas lus. Kev kho kev kho nrog Azacitidine rau Myeleloid leukemia cov neeg mob uas muaj hnub nyoog 75 thiab siab dua.

Venetoclax muaj kev sib txawv rau BH3 khi sau npe ntawm bcoptosis thiab inhibit cell promectation los ntawm kev tshaj tawm siab ntawm bcl {}} hauv aml hlwb. Venetoclax tuaj yeem siv rau kev kho mob ntawm phamphopocytic mob ntsws, mob myeloid leukemia, thiab ntau myeloma.

 

Cov lus txhais lus:

Tshav av dawb

1257044-40-8

Abt -199

VENLLEXTA

GDC -0199

venclyxto

{{0 {0}} [4- [}}}}} {} {5 {5 5}} dimet hylcyclohexen -1-} yl] Methyl] Piperazin {} Yl] -n - [{{10} } nitro -4- (oxan {12}}}}}} b]} {} ake yloxy) benzamide

Venetoclax (abt -199)

Abt -199 (gdc -0199)

Benzamide, {{0 {0}} [{4-}}}}}}}}} d dimethyl {{6 }} cyclohexen -1- yl] meth] {{{} piperazinyl]-} {{} nitr o -4- [[(tetraydro {13}}}}}}} -5- yloxy) -

Abt 199 (Venetoclax)

{{0 {0}} (1h-pyrrolo [2, {}} b] pyridin {} -4- ({ {7}} (({2- ({9}} chlorophenyl)}}}}} dimethylc YCLoHex {12}} Enyl) methyl) piperazin {}}} h-pyran {{} {yl) methy

4- (4- ({} ({}}}}}} dimethylcycl OHEX {-1-}} {7}}}}}} {{{{{}} nitro { 12}} ((tetraydro {13}} h-}}}}}}} b) pyridin {}} yloxy) benzamide

4- (4-} {}}}}}}} {5}} dimethyl cyclohex {6}}}} {}}}}}} yl] methyl}} yl) -n - ({{ }} nitro {{}}} {}} {} {{} {19} loxam} benzamide

 

Cim npe nrov: 1257044-40-8 venetoclax, Tuam Tshoj 1257044-40-8 venetoclax tuam ntxhab, cov chaw muag khoom